2 years ago

MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor

A two-compartment model with linear kinetics can be MAPK pathway activation leads to Bim loss and histone deac read more...

2 years ago

MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor

Romidepsin is transformed in cells to its energetic form by the reduction of the disulfide bond by glutathione,