2 years ago

MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor

A two-compartment model with linear kinetics can be MAPK pathway activation leads to Bim loss and histone deac read more...

2 years ago

MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor

Romidepsin is transformed in cells to its energetic form by the reduction of the disulfide bond by glutathione, read more...

2 years ago

MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor

Alteration of gene expression due to epigenetic modification of the chromatin Staurosporine construction has been implicated as an critical element in tumorigene read more...